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br Experimental procedures br Conflicts of interests br Intr
2022-08-24
Experimental procedures Conflicts of interests Introduction Here we investigate differences in growth properties and short-term morphological changes in response to ET-1 in Chinese hamster ovary (CHO) cells stably and separately expressing ETA or ETB receptors. A stably transfected CHO syst
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br H R agonists In search for potent
2022-08-24
H2R agonists In search for potent and selective H2R agonists, comprehensive structure–activity relationship studies have been conducted and led to the first H2R agonists, e.g. 4(5)-methylhistamine (16) which is actually now used as selective H4R agonist (Fig. 4) (Durant et al., 1975, Lim et al.,
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Finally life expectancy was strongly reduced in STK deficien
2022-08-24
Finally, life expectancy was strongly reduced in STK4-deficient patients. Even in those patients who received haematopoietic stem cell transplantation, the majority of patients died due to transplantation-related complications, raising the question whether MST1 expressed in nonhaematopoietic tissue
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br Introduction Adenosine triphosphate ATP is
2022-08-24
Introduction Adenosine-5′-triphosphate (ATP) is an organic molecule (nucleoside triphosphate) which consists of adenine, ribose, and three phosphoric 5-EdU residues. ATP serves as a temporary carrier of energy in all living cells, so it is a common substance in any organism. In the cells, new AT
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br Materials and methods br Results br Discussion
2022-08-24
Materials and methods Results Discussion Dex has been shown to induce apoptosis in osteoblastic cell lines (MC3T3-E1, UAMS-32 cell) [24], [25]. Consistent with previous reports, we find high-dose Dex (1 or 5 μM) can induce apoptosis of MC3T3-E1 6,7-dihydroxy Bergamottin within 24 h as evid
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Work is presently underway to unveil mechanisms whereby SAHA
2022-08-24
Work is presently underway to unveil mechanisms whereby SAHA-dependent restoration of cardiomyocyte autophagic flux is protective. Another interesting question pertains to mechanisms whereby class I and class II HDAC inhibitors induce autophagy. It has been demonstrated that TSA reduces transverse a
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In fact most PIs are susceptible to substitutions at
2022-08-24
In fact, most PIs are susceptible to substitutions at Asp168, which are often present in patients who fail therapy (Pawlotsky, 2016). Notably, the polymorphism Gln168 at this position underlies reduced efficacy of PIs against GT3 (Soumana et al., 2016a). Glecaprevir and voxilaprevir have improved re
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JDTic 2HCl The stress of accelerated lactate production in c
2022-08-24
The stress of accelerated lactate production in cancer JDTic 2HCl is moderated by the overexpression of lactate transporters – symporters for lactate anions and protons called monocarboxylate transporters (MCTs) – that are capable of bidirectional transport depending on the environmental and/or cell
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br Introduction br Mitochondrial dysfunction and
2022-08-24
Introduction Mitochondrial dysfunction and cancer Lactate and succinate as oncometabolites Intracellular actions of lactate and succinate as tumor promoters Cell-surface receptors for lactate and succinate and their role in cancer GPR109A as the receptor for butyrate and β-hydroxybu
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The Berlin patient is a unique case and
2022-08-24
The Berlin patient is a unique case and dependent on the histocompatibility-matched CCR5Δ32/Δ32 homozygous donors. These donors occur at a little higher rate in the European Caucasian population, but they are very rare in Asians and Africans.15, 16, 17 The recently developed genome-editing technolog
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High energy adjusted free glutamate intake among
2022-08-24
High energy-adjusted free glutamate intake among adults with high education level (above college) or high poverty income ratio (≥3.50) might be a consequence of the difference in intake of some foods such as vegetables and fruits, reflecting upon their socioeconomic status. Previous studies have sho
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Previous reports have showed that the
2022-08-24
Previous reports have showed that the expression and localization of GLUT8 in mouse (Gómez et al., 2006; Kim and Moley, 2007), rat (Ibberson et al., 2002) and human (Schürmann et al., 2002). In this study, GLUT8 protein mainly localized in the spermatocytes, elongated and round spermatids in the adu
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br Introduction Glucose homeostasis is primarily regulated b
2022-08-23
Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β benzydamine is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major counter-regulatory h
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br Secretase modulators a loss of
2022-08-23
γ-Secretase modulators: a loss of pharmacology? A lack of translation from in vitro to in vivo pharmacology is an unresolved issue among most GSMs. R-flurbiprofen was tested in clinical trials, however, it did not achieve statistical significance on either of its primary endpoints – cognition or
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Bile acids BAs are detergent like amphipathic molecules synt
2022-08-23
Bile acids (BAs) are detergent-like amphipathic molecules synthesized from cholesterol in the liver, stored in the gallbladder, and released into the intestine after food intake in order to facilitate the Rosiglitazone maleate of dietary lipids and liposoluble vitamins. BAs travel along the intesti
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