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br Materials and methods br Results
2022-08-18
Materials and methods Results Discussion In this study, we discover that Sufu stabilizes Gli1 protein levels by antagonizing Numb/Itch-mediated protein degradation. Together with previous work that demonstrates control of Gli2/3 protein levels by Sufu (Chen et al., 2009, Jia et al., 2009, W
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br Materials and methods br Results Unitary currents of
2022-08-18
Materials and methods Results Unitary currents of Gardos Pirarubicin mg were identified by their conductance value, inward rectification, voltage independence of open probability, kinetics and Ca2+-sensitivity, all features which have been described elsewhere [8], [13], [20], [23], [24], [25]
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Subsequently BAs are secreted in the portal
2022-08-18
Subsequently, BAs are secreted in the portal vein by the heterodimeric organic solute transporter OSTα/β [15]. At this level, BAs are transported back to the liver, where the great majority is reabsorbed by the sodium (Na)-Taurocholate Cotransporter Protein (NTCP) and organic anion transporting poly
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FPR activation stimulates multiple signal transduction pathw
2022-08-18
FPR1 activation stimulates multiple signal transduction pathways responsible for various neutrophil functions, such as adhesion, chemotaxis, phagocytosis, miniprep of secretory granules, and superoxide anion radical (O2) production, which contribute to the physiological inflammatory response associ
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br The HDC knockout mouse as a
2022-08-17
The HDC knockout mouse as a pathophysiological model of TS The implication of a hypomorphic allele of the Hdc gene as a rare cause of TS (Ercan-Sencicek et al., 2010) created a rare opportunity for the generation of a pathophysiologically grounded model of the disorder. Modeling pathophysiology o
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br Pharmacological anti aging approaches and the
2022-08-17
Pharmacological anti-aging approaches and the Hippo pathway Aging and age-related pathologies are the main causes of disabilities and death. As Magalhañes and colleagues suggest, the challenges of developing anti-aging pharmacological therapies may, in part, be due to the complexity of aging mole
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br Structural studies of GCAP Recoverin was
2022-08-17
Structural studies of GCAP Recoverin was the first member of this subfamily of Ca2+-binding 82 7 to be investigated by structural methods [27], [54], [55], [56], [57], [58]. These proteins have four EF-hands arranged in pairs that give rise to amino- and carboxyl-terminal domains. The crystal st
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PDEs block GUCY C associated second messenger signaling
2022-08-17
PDEs block GUCY2C-associated second messenger signaling by degrading cyclic nucleotides, whereas inhibition of PDEs activity prevents cyclic nucleotide degradation (Fig. 1). Several researchers have described the pathophysiological roles of various PDEs in numerous tumor cell types, including CRC Pr
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br Conclusion and prospect Small GTPases
2022-08-17
5. Conclusion and prospect Small GTPases are very important regulatory proteins of eukaryotes. They play crucial regulatory function in various movement processes of organism [75], [76], [77]. Different nanoparticles used to investigate the interaction with small GTPases inside devd have been su
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As a result of the capability of modulating
2022-08-17
As a result of the capability of modulating the dynamic changes and rearrangement of cytoskeletons, the Rho GTPases, in which RhoA, Cdc42 and Rac1 are best-characterized, have been highlighted as significant contributors for orchestrating neuronal development (Duman et al., 2015, Heasman and Ridley,
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In this study we demonstrate that HHcy upregulated the
2022-08-17
In this study, we demonstrate that HHcy upregulated the expression of GSNOR in T cells. As a result, GSNOR induced denitrosylation of Akt in Hcy-activated T voltage gated potassium channel in vivo and in vitro, which contributed to vascular inflammation and susceptibility to atherosclerosis in GSNO
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br Introduction High dose niacin
2022-08-17
Introduction High dose niacin, or nicotinic acid, has been used as an athero-protective drug for more than 50 years (Carlson, 2005, Offermanns, 2006). When taken in pharmacological doses (>1g/day), the nicotinic kasugamycin form of niacin modulates plasma lipid profiles including decreasing circ
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Pregnancy per AI results at days post TAI tended to
2022-08-17
Pregnancy per AI results at 32 days post TAI tended to differ among GnRH products and was greater for FER and CYS than FAC according to the Tukey-grouping analysis statistical approach (Table 1). In addition, P/AI was greater for cows treated with gonadorelin diacetate products than for cows treated
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Introduction Glycine Fig has two
2022-08-17
Introduction Glycine (Fig. 1; 1) has two pivotal functions as neurotransmitter in the central nervous system (CNS). Firstly, it can act as an inhibitory neurotransmitter at inhibitory glycinergic synapses where it binds to the strychnine-sensitive glycine-A binding site on glycine receptors (GlyR)
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Diabetes induced damage results in peripheral nerve patholog
2022-08-17
Diabetes-induced damage results in peripheral nerve pathology that Magnolol receptor correlates with clinical signs and symptoms. Nerve injury that results in structural changes can be measured through clinical neurological assessment, quantitative sensory testing, nerve conduction studies, and per
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