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br Acknowledgements This work was supported by
2022-08-03
Acknowledgements This work was supported by grants from the Agencia Nacional de Promoción Científica y Tecnológica (PICT2013-0495, PICT2016-1821), and from CONICET (PIP 2013-562), as well as from Fundación René Barón and Fundación Williams. Introduction Histamine poisoning, also known as scom
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GSK461364 CD CD belong to the costimulatory adhesion
2022-08-03
CD80/CD86 belong to the costimulatory adhesion molecule family, which can activate T GSK461364 by the costimulatory pathway and have been used as indicators of DC maturation in numerous studies. In addition, MHC-II, as the principal component of antigen presentation, was significantly elevated after
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Furthermore the role of GSK
2022-08-02
Furthermore, the role of GSK-3 in the pathogenesis of inflammation has been widely documented as it accompanies inflammatory conditions such as diabetes mellitus, mood disorders, Alzheimer’s disease, cancer (Jope et al., 2007), and has been associated with atherothrombotic CVD events. However, anoth
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Acute effects of FZ were not altered in
2022-08-02
Acute effects of FZ were not altered in GluR-A−/− mice, thus providing a solid basis for comparing the effects of repeated drug administration. In addition, GluR-A subunit deficiency did not affect the basal behavior of saline-treated animals, despite the GluR-A−/− mice having been described as hype
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Next we focused on B part the
2022-08-02
Next, we focused on B-part, the phthalazine ring. While both nitrogen atoms of the phthalazine ring were found to be important (data not shown), replacing the benzene ring of the phthalazine part was attempted, and shows the results of the substituted pyridazine rings with bearing 2-methoxy benzene
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It is important to underline that although
2022-08-02
It is important to underline that BTB06584 although ghrelin increases the motivation to eat even in fed state, its effects on food intake and reward are blunted in obese animal models (Zigman et al., 2016). This emphasizes also the interconnection between homeostatic regulation of food intake and r
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The role of GJs in liver fibrogenesis was studied recently
2022-08-02
The role of GJs in liver fibrogenesis was studied recently. Studies showed a significant decrease in liver fibrosis in Cx32 knockout mice compared to wild-type mice. Although the mechanism underlying this protective effect of Cx32 deletion is not clear, reduced oxidative stress was suggested as a po
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We have isolated various bioactive peptides acting
2022-08-02
We have isolated various bioactive 4sc acting by binding to the receptors of endogenous bioactive peptides such as opioid, bradykinin, neurotensin, and complements C3a and C5a etc. [24]. Rubimetide is the first example of an agonist peptide of the FPR2 of exogenous origin. Anxiolytic-like activity
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At the heart of ferroptosis is a
2022-08-02
At the heart of ferroptosis is a process of lethal lipid peroxidation, which is the oxidative addition of molecular oxygen (O2) to lipids, such as polyunsaturated fatty acyl tails in phospholipids. The first descriptions of such enzymatic reactions were in 1955 by Peterson and colleagues [50] and Ro
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Neither E nor Z FPP synthase catalyzed
2022-08-02
Neither E- nor Z-FPP synthase catalyzed the reaction between 8-THPOGPP and IPP. However, a mutant E-FPP synthase (Y81S) produced 12-THPOFPP from the substrates 8-THPOGPP and IPP, and wild-type E-FPP synthase catalyzed the reaction betweeen 8-AcOGPP and IPP producing 12-AcOFPP. Mutant E-FPP synthase
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AZD8186 receptor br Disclosures br Introduction The
2022-08-01
Disclosures Introduction The brown planthopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae), is a classic insecticide-induced resurgent pest throughout Asian rice-growing regions (Chelliah and Heinrichs, 1980). The resurgence of N. lugens induced by commonly used chemical agents has bee
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br Conclusion br Funding br Availability of data and materia
2022-07-30
Conclusion Funding Availability of data and materials Authors' contributions Ethics approval and consent to participate Consent for publication Competing interests Introduction Hepatitis C virus (HCV) infection is a global public health problem. An estimated 71.1 million peop
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In addition to changes in the Rho isoforms
2022-07-30
In addition to changes in the Rho isoforms, all Rac isoforms, including the constitutively active splice variant of Rac1, Rac1b, are overexpressed in various tumors and accumulating evidence indicates that they play an important role in the metastatic potential of cancer Boc-D-Asp(OtBu)-OH.DCHA (Cha
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Barthi et al previously showed that curcumin
2022-07-30
Barthi et al.[43] previously showed that curcumin inhibits IKK complex activity and thus IκBα phosphorylation as well as the p65 nuclear translocation. Those data are in agreement with our results obtained by gel shift assays using GSTP1-1 promoter and consensus NF-κB probes. Moreover, luciferase ac
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Indeed GSTP mRNA appears to be already highly stable in
2022-07-30
Indeed GSTP1-1 mRNA appears to be already highly stable in K562 leukemia FITC, Fluorescein isothiocyanate australia with a half-live of more then 40h which is even further increasing to 92h after hemin treatment and erythroid differentiation. Previous reports quantified GST mRNA half-lives which de
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