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Similarly spectrophotometric titrations were carried out und
2021-12-22
Similarly, spectrophotometric titrations were carried out under conditions identical to those used for the fluorescence titrations. exhibited a predominant flavopiridol receptor band at around 493 nm. The titrations with all G-quadruplex DNAs resulted in a hypochromic effect along with a bathochro
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br Role of FPRs in Cancer br
2021-12-22
Role of FPRs in Cancer Concluding Remarks Activation of FPRs by formylated bacterial peptides or by host-derived mitochondrial peptides is required for local control of infection and wound healing. Nevertheless, various detrimental effects can result from the release of formylated peptides int
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Most hexokinases are widely expressed
2021-12-21
Most hexokinases are widely expressed but distinct hexokinases predominate specific tissues (Katzen and Schimke, 1965, Rogers et al., 1975). Hexokinase I is found in all mammalian tissues, but is most abundant in the ABT 702 dihydrochloride receptor and kidney (griffin et al., 1992). Hexokinase II
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br Hedgehog in chronic liver
2021-12-21
Hedgehog in chronic liver disease The liver responds to different chronic insults with a highly conserved wound healing response during which different cell types must communicate to reconstruct fully functional, healthy liver parenchyma. The inter-cellular dialogue that orchestrates effective li
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br Discussion The present study explored that the
2021-12-21
Discussion The present study explored that the effect of the MTP gene −493G/T polymorphism on the risk of hepatic steatosis in Turkish patients with chronic HCV genotype 1 infection. Some researchers revealed that the MTP gene −493G/T polymorphism was associated with hepatic steatosis in CHC infe
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br Conclusion B esterases and reproductive parameters
2021-12-21
Conclusion B-esterases and reproductive parameters can be used as effect biomarkers of the aquatic contamination with chlorpyrifos. In P. corneus exposed for 14 days to the insecticide, the carboxylesterases determined with p-NFB proved to be the most sensitive biomarker. However, exposure to env
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Castanospermine Main Text There are over
2021-12-21
Main Text There are over 200 small GTPases that play critical roles in diverse fundamental cellular processes such as signal transduction, Castanospermine dynamics, and intracellular trafficking. Most of the GTPases act as switch-like molecules by cycling between the guanosine triphosphate (GTP)-b
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Mice lacking S nitrosoglutathione reductase GSNOR a denitros
2021-12-21
Mice lacking S-nitrosoglutathione reductase (GSNOR), a denitrosylase that regulates S-nitrosylation, have increased levels of S-nitrosoglutathione (GSNO) and exhibit nitrosative stress. GSNO is in equilibrium with protein S-nitrosylation in cells, and GSNOR controls the cellular concentration of pro
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GSK is inhibited by serine phosphorylation at a residue
2021-12-21
GSK-3 is inhibited by serine nevertheless at a residue its N-terminus (Ser 9 in GSK-3β and Ser 21 in GSK-3α) [52], [53], [54]. This raised the possibility that the N-terminal tail may function as a pseudo-substrate by mimicking the pre-phosphorylated substrate. The interaction mode of the pseudo-su
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In the present study we observed a decrease in body
2021-12-21
In the present study, we observed a decrease in body weight gain in Tg rats. It is uncertain whether this effect is due to Denr, Gpr81, or Gpr109a. In this regard, Gpr81 mice have been reported to have reduced body weight gain [28]. Moreover, a small clinical study has reported that obese patients t
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following website We recently reported that the human
2021-12-21
We recently reported that the human-derived PancCa cell line PANC-1 and the human-derived hepatocellular HepG2 cell line express GPR55 mRNA and protein [21]. In PANC-1 and HepG2 cells, knockdown of GPR55 with specific siRNAs abrogates cellular uptake of Tocrifluor 1117, a selective GPR55 ligand [21]
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br Manganese based imaging probes br Imaging of vesicular mo
2021-12-21
Manganese-based imaging probes Imaging of vesicular monoamine transporter 2 (VMAT2) Imaging of sulfonylurea receptor 1 (SUR1) In mammals, insulin secretion is mediated by the membrane potential of pancreatic β-cells. Increases in glucose levels lead to blocking of ATP-sensitive potassium ch
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GPR co localizes with ghrelin in the duodenum
2021-12-21
GPR120 co-localizes with ghrelin in the duodenum [17], α-gustducin in the small intestine and type II taste bud cells 18, 19, neuropeptide Y centrally in the arcuate nucleus [20] and glucagon-like peptide 1 (GLP-1) in the colon and circumvallate papillae taste bud cells 6, 21, 22. Interestingly GPR1
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br Conclusions br Acknowledgements br Introduction Glucose
2021-12-21
Conclusions Acknowledgements Introduction Glucose metabolism is vital to prepare uterine epithelium and stroma for embryo implantation and for the differentiation of the functionalis layer to support the developing conceptus [[1], [2], [3], [4]]. Due to its polar nature and hydrophilic cond
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A significant contribution to the discovery of novel Hh
2021-12-21
A significant contribution to the discovery of novel Hh inhibitors is given by natural compounds [11,17,22,31,32]. The first Hh inhibitor ever discovered has been Cyclopamine, a steroidal alkaloid isolated from plants of the Veratrum species [13,33]. Subsequently, many natural compounds belonging to
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