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br Materials and methods br Results br
2021-12-09
Materials and methods Results Discussion Main results obtained in this work are presented in Table 1 and can be summarized as follows: 1) AEA inhibits FcεRI receptor-induced degranulation with the participation of CB2 and GPR55 receptors by a PTX-insensitive mechanism; 2) AEA does not block
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Afatinib dimaleate br Vertebrate steroid receptor evolution
2021-12-09
Vertebrate steroid receptor evolution Conclusion The teleost WGD event resulted in the duplication of the vertebrate GR and MR and two GRs have been retained in the majority of teleost fish studied so far. The molecular basis for this retention has yet to be fully understood. The cloning of th
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Some but not all GSIs inhibit signal peptide peptidases
2021-12-09
Some, but not all, GSIs inhibit signal peptide peptidases as well, though this has not been systemically studied [36], [41]. When considering biological activities of various GSIs this is an important and understudied caveat that could influence both biological response as well as potential toxiciti
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br Materials and method http www
2021-12-09
Materials and methods Results Discussion This study provide for the first time a report on GALP in fish, providing new information towards the distribution and functional characterization of the galaninergic system in these vertebrates. Our studies show the detailed neuroanatomical distribu
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G quadruplex structures can be resolved by helicases Consist
2021-12-09
G-quadruplex structures can be resolved by helicases. Consistently, many helicases are aberrantly expressed in cancer Exo1 [47]. In this study, we correlated HOXC10 expression with that of all helicases using a microarray dataset derived from 759 breast cancer patients [36] and discovered that CHD7
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FGF signals can be transduced to the signaling cascades
2021-12-09
FGF signals can be transduced to the signaling cascades of RAS-MAPK or PI3K-AKT through FRS2 and GRB2, to the pathways of PKC or PKD via PLCγ and DAG, and to Ca2+-releasing cascade via PLCγ and IP3, finally affecting cellular proliferation, cellular survival, and angiogenesis [48]. By increasing syn
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It has been reported that aberrant GPR expressions
2021-12-09
It has been reported that aberrant GPR120 expressions were detected in colorectal carcinomas, compared with normal tissues. In addition, GPR120 stimulated cell motile activity and angiogenic property in colon cancer cells [10]. Recently, we indicated that GPR40 suppressed cell motile and invasive ac
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br Results br Discussion Our
2021-12-09
Results Discussion Our studies highlight MUFAs as key lipid modulators of both non-apoptotic and apoptotic cell death. Recent studies show that a more mesenchymal phenotype, de-differentiation, and acquired resistance to targeted inhibitors, can all promote a ferroptosis-sensitive cell state (
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Psora 4 Introduction Vesicular exocytosis an intracellular m
2021-12-09
Introduction Vesicular exocytosis, an intracellular membrane trafficking pathway, is a ubiquitous process for intercellular communication. It occurs when an intracellular vesicle fuses with the cell membrane and subsequently releases an infinitely minute number of chemical or biochemical messengers
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To our knowledge the putative role of ET
2021-12-09
To our knowledge, the putative role of ET-1 and ETB-R in oligodendroglioma progression was not documented so far. Using primary cultures of grade B oligodendroglial tumor cells, we have here assessed the functionality of ETB-R expression in these tumors. Confocal microscopy analysis confirmed the st
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br The SRP SR Heterodimer
2021-12-08
The SRP/SR Heterodimer: GTPase Tangos Drive Co-Translational Protein Targeting SRP and SR mediate a universally conserved protein targeting pathway responsible for the delivery of 25–30% of newly synthesized proteome to the eukaryotic endoplasmic reticulum (ER) or the bacterial plasma membrane 11
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br GSNOR regulates SA synthesis and SA
2021-12-08
GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic dormin (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resistance, l
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br Discussion Recent progresses in osteoblast biology reveal
2021-12-08
Discussion Recent progresses in osteoblast biology reveal that aerobic glycolysis was the main pathway to supply energy and materials that need by osteoblast differentiation [3]. In current study, we showed that LA enhanced the effect of PTH on osteblast differentiation and revealed an unrecogniz
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Compound was synthesized in a racemic
2021-12-08
Compound was synthesized in a racemic fashion with this study and plans for an enantioselective synthesis could be developed based on the activity of racemic . Synthesis of compound followed a slightly different synthetic route due to the ineffectuality of the S2 reaction on the secondary position
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Recently several groups reported that four orphan
2021-12-08
Recently, several groups reported that four orphan receptors, GPR40, GPR41, GPR43, and GPR120, can be activated by free fatty acids. Short-chain fatty acids are specific agonists for GPR41 and GPR43 . Medium and long-chain fatty acids can activate GPR40 and GPR120 . Our previous report showed that a
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