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Recently pharmacological studies have revealed
2021-08-31
Recently, pharmacological studies have revealed that natural compounds achieve increasing attention due to its high therapeutic effectiveness and low adverse effect, compared with the chemically synthesized compounds. Emodin is a kind of natural anthraquinone derivative enriched in traditional Chine
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br Materials and methods br Results
2021-08-31
Materials and methods Results Discussion The effect of progestogen treatment showed some tendencies affecting the body length and weight, however these data were not verifiable statistically. This observation could be explained with the relatively short exposure period and/or the relatively
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br Experimental Procedures br Author
2021-08-31
Experimental Procedures Author Contributions Acknowledgments We thank the Mouse Modeling, Integrated Microscopy, and FACS Facilities of IGB-CNR, Naples. Dr. Laura Pisapia is acknowledged for flow cytometry analyses. We are grateful to Prof. Chris Ponting and George A. Calin for insightful s
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br Conflicts of interest br Acknowledgements This
2021-08-31
Conflicts of interest Acknowledgements This work was supported, in part or in whole, by the grants from the National Natural Science Foundation of China (11802056, 11772088), the China Postdoctoral Science Foundation (2018M640904), and the Fundamental Research Funds for the Central Universitie
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Artificial permutations have also been exploited
2021-08-31
Artificial permutations have also been exploited by protein engineering to manipulate protein scaffolds, in order to improve catalytic activity, alter substrate or ligand binding affinity, reduce proteolytic susceptibility, increase stability, generate different aggregation states and improve fluore
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Why are Tfh cell dynamics so fundamentally different
2021-08-31
Why are Tfh cell dynamics so fundamentally different in naive and immune animals? Initially, GC Sunitinib receptor must pass stringent affinity and specificity checkpoints to ensure only high-affinity non-self-reactive cells are selected. Therefore, restricting primary Tfh cells with the greatest h
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br Acknowledgments br Introduction Inflammation is the prote
2021-08-31
Acknowledgments Introduction Inflammation is the protective reaction of the body to infection, injury, or irritation with the aim to remove harmful stimuli such as pathogens, damaged cells, or allergic irritants and to initiate the healing process. Inflammatory abnormalities play a crucial rol
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phospholipase a2 inhibitor Impaired dopaminergic systems ass
2021-08-30
Impaired dopaminergic systems associated with MA have been well-documented (Walsh and Wagner, 1992, Kim et al., 1999, Nakajima et al., 2004, Shin et al., 2012, Shin et al., 2017b, Dang et al., 2016, Dang et al., 2017b). Previous reports have suggested that early MA use may be linked to higher risk f
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br Introduction Vitis vinifera L is one of the most
2021-08-30
Introduction Vitis vinifera L. is one of the most worldwide-grown fruit crop and is mostly used in the wine industry (Bouquet, 2011). Domestication and history changed dramatically the biology of this species and today there are thousands of V. vinifera varieties, being many of them closely relat
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In conclusion over expression of Stokesia epoxygenase SlEPX
2021-08-30
In conclusion, over-expression of Stokesia epoxygenase (SlEPX) in soybean seeds led to some unusual seed phenotypes. These effects can be overcome by coexpression of Vernonia DGATs (VgDGAT1 & 2). The DGATs can specifically transfer vernolic lrrk2 into TAG, largely reducing vernolic acid levels in m
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dihydrochloride Culture conditions particularly temperature
2021-08-30
Culture conditions (particularly temperature), which affect the pathogenicity of Y. enterocolitica (Bottone, 1997), may also impact its inhibitory properties against cysteine proteases. However, culturing the bacterial strains at 37 instead of 28 °C did not alter remarkably the inhibitory potential
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Our results for imidacloprid were unexpected considering tha
2021-08-30
Our results for imidacloprid were unexpected: considering that imidacloprid (Im) is a neonicotinoid insecticide with a different mode of action (agonist of the nicotinic sto products receptor) than OPs, we expected Es-ChE and T-ChE activity to be largely insensitive to changes in Im concentrations.
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We analyzed whether HaCaT cells treated with PLD can
2021-08-30
We analyzed whether HaCaT fura 2 am sale treated with PLD can alter the expression of genes involved in DNA damage response. Key DNA damage cues activate the sensory DNA-PK/ATM/ATR kinases, which relay two parallel cascades that ultimately serve to inactivate the Cyclin B-cdc2 complex. The protein k
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In summary we elucidated the in vitro activities
2021-08-30
In summary, we elucidated the in vitro activities of KDM1B in regulation of PC cell proliferation and apoptosis. These studies provided a novel insight into the previously unrecognized roles of KDM1B in human PC cells. We showed for the first time that KDM1B knockdown attenuated proliferation and in
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Bexarotene synthesis br EBV Infection Epstein Barr virus
2021-08-30
EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt's lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). Th
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