• br STAR Methods br Acknowledgments We

  2020-07-31

  

  STAR★Methods Acknowledgments We thank A. Rongvaux, L. Evangelisti, J. Stein, C. Hughes, and L. Borelli for help with generating Gpr183−/− mice. We also thank L. Zenewicz for providing cDNA and G. Eberl (Pasteur Institute) for providing Rorc(γt) transgenic mice. R.A.F. is an investigator of the

• Mutation of RING type E s

  2020-07-31

  

  Mutation of RING-type E3s, or modulation of their activity in other ways, is often associated with human disease. BRCA1, an E3 that plays critical roles in DNA repair, is mutated in familial breast and ovarian cancers [2]. Mutations in components of the FANC ubiquitin ligase, also involved in DNA re

• There is plenty of evidence

  2020-07-31

  

  There is plenty of evidence that rs1611115 effects phenotypes related to catecholaminergic activity. With respect to drug addiction carriers of the TT genotype show increased severity of heroin use (Xie et al., 2013) and poorer cocaine treatment outcomes (Kosten et al., 2013). Moreover, disulfiram,

• BRD 7552 Interestingly despite high circulating dILP and dIL

  2020-07-31

  

  Interestingly, despite high circulating dILP2 and dILP5 levels in fru > Dgk RNAi flies, overall insulin signalling pathway activity was attenuated suggesting that these flies are insulin resistant. These results are consistent with previous studies that showed that flies, like mammals, develop insul

• Case report A year old man presented

  2020-07-30

  

  Case report A 41-year-old man presented with 2 weeks of bilateral, painless vision loss in the absence of any systemic symptoms. On initial examination, visual acuity measured 20/125 OD and 20/1250 OS. Goldmann perimetry showed bilateral, cecocentral scotomas, with complete loss of the I2e isopter

• In addition to neutral lipid

  2020-07-30

  

  In addition to neutral lipid accumulation, our study also illuminated that DGAT2 from N. oceanica could alter the composition of fatty acids. The results showed the strong correlation between neutral lipid content and fatty acid, because fatty alverine content was considered to be an important para

• Three DDR binding sites have been mapped on

  2020-07-30

  

  Three DDR2 binding sites have been mapped on the collagen triple helix by us for collagen type 1 and by others using the collagen toolkit for collagen type 2. All of the three reported binding sequences are conserved in the α1 chain of collagen types 1, 2 and 3. The central motif sequence GARGQAGVMG

• We show here that Shp binds to phosphotyrosine

  2020-07-30

  

  We show here that Shp-2 binds to phosphotyrosine-740 in the cytoplasmic domain of DDR1 in a collagen-dependent manner (Figs. 3A and 4A). The peptide sequence ISpYPML neighboring tyrosine 740 matches well with the immuno-receptor tyrosine-based inhibitory motif (ITIM)-consensus sequence [I/V/L]XpYXX[

• It is well established that

  2020-07-30

  

  It is well established that CRF action is triggered by its binding to CRF1 or CRF2, two G protein-coupled receptors (GPCR). Perhaps the principal or best-known action mechanism following activation of both CRF receptors is through stimulatory G protein activation (GsP), which in turn stimulates the

• br Conflict of interest br Acknowledgments Part of this

  2020-07-30

  

  Conflict of interest Acknowledgments Part of this work was supported by Institut Francais en Egypte, and the Academy of Scientific Research and Technology in Egypt under the frame of “Imhotep Project N°: 31681XL” and “STDF/IFE project N° 30630″ Introduction NSAIDs play an important role in

• Accumulated evidence indicates that apelin plays a protectiv

  2020-07-30

  

  Accumulated evidence indicates that apelin plays a protective role in ischemic stroke, contributing to post-stroke recovery (Yang et al., 2014; Chen et al., 2015; Xin et al., 2015; Yan et al., 2015). Apelin gene (APLN) encodes prepro-apelin with 77 amino acids, while the C-terminal 23 Cy5.5 carboxyl

• The metal exposures with Cd and Cu revealed sensitivity

  2020-07-30

  

  The metal exposures with Cd and Cu revealed sensitivity of T-ChE and Es-ChE activity in Saccostrea at concentrations > 100µg/L Cd, most notably so in digestive gland, where activities of both enzyme fractions decreased nearly 3-fold relative to controls at the highest exposure concentration (1000µg/

• We previously reported that the changes in

  2020-07-29

  

  We previously reported that the changes in the expression level of DGKδ2 affect C2C12 myogenic differentiation [39]. Proteostasis requires both protein synthesis and degradation. Indeed, protein degradation via the ubiquitin-proteasome and autophagy-lysosome systems is important for skeletal muscle

• The in vivo anti inflammatory effect

  2020-07-29

  

  The in vivo anti-inflammatory effect of Ivachtin was further completed using the functional model of adjuvant induced arthritis (AIA) in rats as shown in . Compound was shown to be active in the AIA model, although with a lower potency than teriflunomide. These results are not surprising in the lig

• CPG a metalloenzyme derived from sp was

  2020-07-29

  

  CPG2, a metalloenzyme derived from sp., was the elected enzyme for the first pilot-scale clinical trial of ADEPT. This enzyme has no mammalian homologue and activates glutamic Boc-D-Asp(OtBu)-OH.DCHA prodrug derivatives of several nitrogen mustards alkylating agents., , , , , A bond cleavable by

14208 records 783/948 page Previous Next First page 上5页 781782783784785 下5页 Last page