Effects of estradiol outside the nucleus are

2019-08-27

Effects of estradiol outside the nucleus are often mediated by classical estrogen receptors Today, it is widely accepted that steroid hormones can signal in ways that do not rely on receptors acting in the nucleus, including activation of receptors localized to the cellular membrane. Rapid effects of estradiol were first observed in uterine tissue over 50 years ago (Szego and Davis, 1967).

Using characteristic features of ECM proteins

2019-08-26

Using characteristic features of ECM proteins and a computational pipeline combining interrogation of protein and gene databases, we previously defined the matrisome as the ensemble of ECM and ECM-associated proteins [[16], [17], [18]].

Valproic Fmoc-Cl (VPA) is a first-line treatment

2019-08-24

Valproic Fmoc-Cl (VPA) is a first-line treatment for epilepsy and bipolar disorder, although its therapeutic mechanism of action is not fully understood. Considerable evidence suggests that VPA can act through the GABAergic system, NMDA receptors, and/or sodium channels (for review, see Löscher, 1999, Löscher, 2002, Rogawski and Löscher, 2004).

Although intact Chk is distributed throughout

2019-08-23

Although intact Chk is distributed throughout the nucleus and the cytoplasm (Fig. 1), the deletion of the SH2 domain greatly augments nuclear localization of Chk.

Introduction Ewing sarcomas/primitive

2019-08-22

Introduction Ewing sarcomas/primitive neuroectodermal tumors (ES/PNETs) are relatively infrequent but the second most common sarcoma of the bone next to osteosarcoma.

ELUXA 1 (HM-EMSI-202) is an ongoing pivotal Phase

2019-08-21

ELUXA 1 (HM-EMSI-202) is an ongoing pivotal Phase II global clinical trial, designed to further investigate the efficacy and safety of Olmutinib in patients T790M-positive NSCLC with acquired resistance after first-line EGFR TKIs.

Recently it has been shown that among the

2019-08-20

Recently, it has been shown that among the ELR (+) chemokines mentioned above, particularly IL-8 induces neutrophil migration via CXCR-1 chemokine receptor. For example, Godaly et al.

CDK6 lacks DNA-binding domains and nuclear localization

2019-08-19

CDK6 lacks DNA-binding domains and nuclear localization sequences, and therefore will probably be transported to the nucleus by a ‘piggy-back’ mechanism and needs to contact its specific sites indirectly through DNA-binding proteins. Besides NF-κB p65, a further candidate transcription factor is PAX4 (paired box 4), whose consensus DNA-binding motif is associated with a fraction of CDK6 peaks.

Rationale and Conventional Use of Alkylating

2019-08-17

Rationale and Conventional Use of Alkylating Agents and Platinum Derivatives in Clinical Practice After the attack on Bari Harbor in 1943 revealed the effects of mustard gas on bone marrow depletion and the first therapeutic outcomes in lymphoma, alkylating agents gradually became a gold standard as first-line treatment for various cancer indications.

Since both the Ub and ISG15 systems

2019-08-16

Since both the Ub and ISG15 systems are crucial for the innate immune response, many prokaryotic and viral pathogens have evolved ways to hijack them in order to create a “window-of-opportunity” for efficient replication.

At present there have been relatively

2019-08-15

At present, there have been relatively few studies that evaluated potential correlations between pulmonary and pleura metastases, hilar and mediastinal Gardiquimod nodes, and organs associated with distant metastasis and EGFR mutations [33,34,37].

The present work shows that normal climatic

2019-08-14

The present work shows that normal climatic conditions are not critical for the long time survival of DNA in untreated blood stains.

Due to the high attractiveness of E2

2019-08-13

Due to the high attractiveness of E2 and E3 ligases as drug targets, a number of drug discovery assays have been published, based on detection by fluorescence

Hello world!

2018-07-29