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Lipotoxicity is the accumulation of excess lipids in non
2024-07-08
Lipotoxicity is the accumulation of excess lipids in non-adipose tissues that leads to cell dysfunction or cell death. It may play an important role in the pathogenesis of diabetes, and contributes to the rate of progression of CKD [7,8]. Emerging evidence indicates that renal lipid dysregulation is
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br Experimental procedure br Introduction Migraine
2024-07-08
Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of
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E7046 Anti LT therapy by LO inhibition
2024-07-06
Anti-LT therapy by 5-LO inhibition has been hampered by occurring liver toxicities by Zileuton or the clinical phase II compound Atreleuton [36], [37] However both compounds possess a thiophene as well as an N-hydroxyurea moiety. These features could be linked with reactive thiophene intermediates [
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br Conclusion The HT receptor family is complex
2024-07-06
Conclusion The 5-HT receptor family is complex, and one may ask as does Bryan Roth et al. [205] whether this is useless 5(S),6(R)-7-trihydroxymethyl Heptanoate (i.e. too much redundancy) or an embarrassment of the riches (i.e. many potential targets to choose from to affect normal or pathological
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br Conflict of interest statement br
2024-07-06
Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal flt3 in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within these 2 cellular compartmen
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Loss of expression or functional activity of cell adhesion
2024-07-06
Loss of expression or functional activity of cell adhesion is intricately related to advanced stages of tumour progression and invasiveness. Martin-Belmonte and Perez-Moreno recently mentioned that the deregulation of adhesion can alter tumourgenesis in the early stage. We have shown for the first t
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While high fat diet models of
2024-07-06
While high-fat diet models of insulin resistance are acceptable approaches for the study of pre-diabetes in humans, they are not suitable for modeling progression towards established type2 diabetes. The pattern of activation of the lipoxygenase pathway in pre-clinical models of type2 diabetes has no
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br Materials and Methods br Results
2024-07-06
Materials and Methods Results Discussion 15-HETE is a predominant eicosanoid in pulmonary vascular remodeling, and it could promote hypoxia-induced PAH via its involvement in the regulation of proliferation and cell cycle progression in PASMCs. To understand its role in HPH, we have previou
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The reasons why antibiotic treatment may be detrimental are
2024-07-06
The reasons why antibiotic treatment may be detrimental are diverse. First, it may result in disruption of multifaceted microbe–microbe, as well as microbe–host, interactions that are key for the maintenance of homeostasis within this ecosystem. This can lead to the expansion of pathogenic microorga
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In this study we have
2024-07-06
In this study, we have generated new FRET reporters to screen all submembrane domains of AT1R for interactions with CaM. We identified a new CaM-binding domain on the receptor’s SMD2 (a.a. 125 – 141), confirmed interactions at SMD4JM (a.a. 309 – 327) and characterized the full interacting domain in
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br Introduction Alzheimer s disease AD is
2024-07-05
Introduction Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia. It is characterized by progressive and irreversible damage to different BRD 7389 mg areas, resulting in cognitive impairment and behavioral changes (O'Neill, 2013, De Strooper and Karran, 201
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Voluminous literature about the neuroendocrine mechanism of
2024-07-05
Voluminous literature about the neuroendocrine mechanism of reproduction and energy regulation has emerged from studies involving mammalian species. The avian infundibular nucleus (equivalent structure to the mammalian arcuate nucleus) consists of two neuronal populations, one of which expresses ne
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The PDZ domains of DLG interact with tumor suppressor protei
2024-07-04
The PDZ domains of DLG interact with tumor suppressor proteins, APC and PTEN, as well as with several viral oncoproteins such as the E6 protein present in oncogenic human papillomavirus (reviewed in [177]). It has been reported that overexpression of DLG in fibroblasts impairs the events in the G0/G
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Although many factors influence the effects of medications
2024-07-04
Although many factors influence the effects of medications, during recent years it has become evident that genetic factors could explain the differences between individuals in drug response. These differences are due to variants in genes encoding drug targets [8]. The challenge for pharmacogenetics
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The putative physiological meaning of epinephrine related he
2024-07-04
The putative physiological meaning of epinephrine-related hepatic drug transporter regulation remains to be established. It is nevertheless noteworthy that the catecholamine rather decreases expression of sinusoidal SLC transporters like NTCP, OAT2, OAT7, OCT1, OATP1B1 and OATP2B1 whereas those of c
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