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How do myofibroblast sources compare between bone marrow and
2021-09-13
How do myofibroblast sources compare between bone marrow and other organs? Perivascular Lck Inhibitor with MSC properties significantly contribute to fibrosis in muscle, fat, skin, heart, kidney, lung, and liver (reviewed in Iwayama et al., 2015) and activate Gli1 in many of these organs (Kramann e
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By association a possible mechanism which may underlie the
2021-09-13
By association, a possible mechanism which may underlie the progression of seizures is long-term potentiation (LTP). Indeed, LTP shares many common mechanisms with seizures activity both anatomically and physiologically, and has been implicated as a mechanism of acute epileptogenesis (Wasterlain et
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Following optimization chemicals which were considered as th
2021-09-13
Following optimization, 31 chemicals, which were considered as the skin sensitizers and non-sensitizers in LLNA studies, were studied for their potential of β-galactosidase suppression (Table 2). The detailed information on test chemicals used were given in Table 1. With optimum cell densities, E. c
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br Conclusions Osteoclcastogenesis is regulated by multiple
2021-09-13
Conclusions Osteoclcastogenesis is regulated by multiple signal transduction pathways. To maintain bone homeostasis, osteoclast cells must achieve a balance regulation of formation, function, and trafficking of its precursors. Here, we proposed a model in which crosstalk between Fas and S1P/S1P1
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Senger et al performed a retrospective review
2021-09-13
Senger et al. performed a retrospective review of 17 patients with ICH on dabigatran or rivaroxaban who received 4F-PCC. Eight patients had a traumatic QNZ injury (TBI) and nine patients had a spontaneous ICH. Nine patients had a devastating outcome, including severe neurologic deficits, comatose st
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In the course of an internal
2021-09-13
In the course of an internal FAAH, program,, , , , , , , , , , , , , many very similar compounds were profiled in vivo with particular interest paid to their ability to penetrate the BBB. The compounds profiled were heteroaryl piperazinyl and piperadinyl ureas; a class of compounds, reported on prev
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In hypoxic breast cancer cells BNIP
2021-09-11
In hypoxic breast cancer cells, BNIP3-mediated autophagy activation and elevation of amino A-1155463 levels were notable. BNIP3, a BCL-2 family protein, is known to be transcriptionally regulated by HIF-1α and to be involved in cancer cell death in hypoxic conditions [51]. As a link to autophagy, h
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Experiments conducted on the human parasite Leishmania
2021-09-11
Experiments conducted on the human parasite Leishmania major has shown that specific parasitic antigens are involved in steering the immune responses to “protective” as opposed to “disease” state (Reiner et al., 1993; Reiner and Locksley, 1995; and Sjölander et al., 1998) and that antigenic composit
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EAAT glutamate uptake is driven by the co transport of
2021-09-11
EAAT glutamate uptake is driven by the co-transport of three sodium ions and one proton, as well as the counter-transport of one potassium ion (Fig. 1B). This complex stoichiometry frees up enough energy to permit Doripenem of glutamate into the cell against a steep concentration gradient. Addition
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Previous studies have suggested that GPR protects from
2021-09-11
Previous studies have suggested that GPR40 protects from bone loss via inhibition of osteoclasts. Wittrant et al. used GPR40 knock-out mice and primary osteoclasts to investigate the role of GPR40 on bone remodelling. Their results in primary osteoclast cultures and the RAW264.7 cell line showed tha
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Cysteine Cys residues are frequently
2021-09-11
Cysteine (Cys) residues are frequently found to be highly conserved within functional, regulatory, catalytic, or binding sites of proteins. Thiol or thiolate chemistry imparts active sites with unique properties like nucleophilicity, high affinity metal binding, and disulfide bond assisted multimeri
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Introduction Soluble guanylyl cyclase sGC is a key protein i
2021-09-11
Introduction Soluble guanylyl cyclase (sGC) is a key protein in the regulation of multiple physiological functions in mammalian physiology [1,2]. Upon stimulation by nitric oxide (NO) [3], sGC generates cyclic guanosine monophosphate (cGMP) from guanosine-5′ triphosphate and activates protein kinas
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CRT0044876 GT cells were treated in two
2021-09-11
GT1-7 CRT0044876 were treated in two ways; specifically, they were either dosed or transfected with VP, reflecting the extracellular and intracellular actions of VP, respectively. A dose of 200 pg/ml VP in culture supernatants was effective in stimulating GnRH in the supernatant and cell extracts;
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br Results and discussion br Conclusion In conclusion our
2021-09-11
Results and discussion Conclusion In conclusion, our present results indicated that l-glutamate treatment could induce resistant to B. cinerea in postharvest tomatoes. The control effect was probably associated with up-regulating the glutamate receptor-like genes, PR genes and the accumulation
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Glucagon regulates the transition from hepatic
2021-09-11
Glucagon regulates the transition from hepatic glucose utilisation in the absorptive state to glucagon production in the post-absorptive state by acute stimulation of glycogenolysis and inhibition of glycolysis [1]. An important component of this response is the phosphorylation of liver PFK2/FBPase2
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