• The Notch cleavage efficiency of Aph aS containing complexes

  2021-11-08

  

  The Notch-cleavage efficiency of Aph1aS containing complexes was lower than that of Aph1aL γ-secretases, especially in combination with PS2, suggesting that Aph1aS is a determinant of low Notch-cleavage specificity, considering that the different subcellular localization of PS1 and PS2 didn't affect

• PK profiles of were evaluated

  2021-11-08

  

  PK profiles of were evaluated and found to be improved compared to compound presumably due to interruption of β-oxidation. Low clearance and high plasma exposure were considered to be suitable profiles as an oral agent (). We first examined in vitro insulinotropic effects of compound from MIN6 c

• br Future perspectives A plethora

  2021-11-08

  

  Future perspectives A plethora of reports from in vivo and in vitro human and animal studies have demonstrated the potential role of FGFR signalling in human carcinogenesis, whether it be in an oncogenic or tumour suppressive capacity. It is still not well understood how FGFRs can act as tumour s

• Taken together our studies uncovered that the RP

  2021-11-08

  

  Taken together, our studies uncovered that the RP215 antibody recognize a novel CIgG molecule N-glycan modification at a non-consensus site within the CH1 domain expressed in LSCC tumors. RP215-CIgG interacts with the integrin α6β4 complex and the unique N-glycan epitope mediates the activation of d

• br Application of TIRFM to visualizing exocytosis TIRFM was

  2021-11-08

  

  Application of TIRFM to visualizing exocytosis TIRFM was first used to visualize exocytosis from large secretory granules from chromaffin 2 deoxy d glucose mg (Steyer et al., 1997). Before that, visualization of secretory organelle was strictly limited to a few exceptions, such as mast cell of m

• In a preliminary communication we showed that AT and

  2021-11-08

  

  In a preliminary communication, we showed that AT and ETB receptors colocalize and coimmunoprecipitate in renal proximal tubule cells, and stimulation of the AT receptor increases ETB receptor expression in Wistar-Kyoto (WKY) rats [abstract; Zeng C,, 26:80A, 2003]. We hypothesize that the ETB recept

• The neurotransmitter histamine plays a key role in the sleep

  2021-11-08

  

  The neurotransmitter histamine plays a key role in the sleep-wake cycle and in learning and memory. Alterations in Gallein histamine levels are closely connected with central nervous system dysfunction, and are thought to contribute to neurological disorders, including Alzheimer's disease and depres

• Importantly recent in vivo results demonstrated that

  2021-11-08

  

  Importantly, recent in vivo results demonstrated that combining an HDACi and a IKK inhibitor significantly reduced ovarian tumor growth compared with either inhibitor alone [26]. The slowest tumor growth in the HDACi/IKK inhibition combination group was associated with the lowest CXCL8 tumor and pla

• Modulation of the cannabinoid system

  2021-11-06

  

  Modulation of the cannabinoid system has been reported to exert anti-parkinsonian properties through different mechanisms. On one hand, cannabinoids have neuroprotective properties in different rodent models of PD, both through a CB1/CB2 receptor-independent mechanism (Lastres-Becker et al., 2005) a

• So far several methods have been

  2021-11-06

  

  So far, several methods have been used to monitor the level of GJC and its regulation in astrocytes studied in acute FRAX486 slices (see Giaume et al., 2012). This mainly includes approaches based either on electrophysiological properties of gap junction channels or on “dye coupling” experiments th

• uPAR promotes cell associated proteolysis

  2021-11-06

  

  uPAR promotes cell-associated proteolysis by binding to uPA which locally converts plasminogen into active plasmin [10]. Ligand-engaged uPAR also acts as a potent regulator of cell migration and matrix attachment. Being a membrane receptor, uPAR needs to interact with extracellular matrix (ECM) prot

• Previous research has suggested that differences

  2021-11-06

  

  Previous research has suggested that differences in spatiotemporal regulation of intracellular signaling pathways can confer specificity to cellular responses (Marshall, 1995). Conventional approaches based on gain- or loss-of-function genetic manipulations or small-molecule inhibitors, however, lac

• Septic shock a condition where

  2021-11-06

  

  Septic shock, a condition where endothelium-derived substances most likely play an important role, is often accompanied by cardiac dysfunction, pulmonary hypertension, systemic hypotension and impaired oxygen utilisation with systemic acidosis (Vincent, 1998). Experimental endotoxaemia shows a simil

• TW-37 While considering the molecular pathogenesis of an MPN

  2021-11-06

  

  While considering the molecular pathogenesis of an MPNST, the Ras/Raf/MEK/ERK, mTOR/AKT, p53, and PTEN pathways associated with tumor growth have been described (McCubrey et al., 2012). The involvement of receptor tyrosine kinases such as EGFR and TAM receptor families, and its associated molecular

• Introduction Epigenetic mechanisms modulate heritable phenot

  2021-11-05

  

  Introduction Epigenetic mechanisms modulate heritable phenotypic changes that are not dictated by changes in DNA sequences. The link between epigenetic modifications and cancer development has been established [1], [2]. Histone modifications represent an important class of epigenetic mechanisms tha

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