• Following DEX exposure the levels

  2021-05-12

  

  Following DEX exposure, the levels of CYP1A1 protein and activity remained unchanged, as seen in our previous in vitro study (Burkina et al., 2013). Dasmahapatra and Lee (1993) reported that 3.9μgL−1 DEX, similar to our highest tested concentration, did not change CYP1A1 protein content. An increase

• br Results br Discussion The ubiquitin system has in

  2021-05-12

  

  Results Discussion The ubiquitin system has in recent years become an exciting area for drug discovery (Cohen and Tcherpakov, 2010), as multiple enzymatic steps within the ubiquitylation process are druggable. The potential of targeting the ubiquitin-proteasome pathway was first demonstrated i

• ibmx In a study carried out

  2021-05-12

  

  In a study carried out by Aunis et al. the properties of soluble DBH and membrane bound were examined [23]. The membrane bound enzyme was shown in ibmx to the soluble form to have thermal denaturation at higher temperatures of 43.5–44°C. Similar discontinuities in the Arrhenius plots were obtained

• The results described in the present study confirm

  2021-05-12

  

  The results described in the present study confirm key restrictions on reaction conditions which must considered to maximize reactor productivity. Increased viscosity should be avoided for the amination of ketones by L-AmDH, as a 4-fold increase in viscosity can lower the reaction rate by as much as

• Cysteinyl leukotrienes CysLTs are potent inflammatory mediat

  2021-05-12

  

  Cysteinyl leukotrienes (CysLTs) are potent inflammatory mediators closely associated with cerebral ischemic injury. CysLTs induce inflammatory responses mediated by at least two different CysLT receptors (CysLT1R and CysLT2R) (Bäck et al., 2011, Singh et al., 2010). It has been reported that the Cys

• Concerning firmness postharvest calcium dips

  2021-05-12

  

  Concerning firmness, postharvest calcium dips for whole fruit have been demonstrated to preserve firmness, cell wall structure (Glenn and Poovaiah, 1990), nutritional quality (Goldberg, 1984) and fruit flavour (Ortiz et al., 2009). Similarly, combinations of calcium treatment (0.5–4%) with packaging

• Completion of h of education was significant

  2021-05-12

  

  Completion of 150 h of education was significant in virtually all prior studies of the 150-h requirement (Allen and Woodland, 2006, Boone et al., 2006 and others). While the 150-h requirement applies to licensure, students are often permitted (as in California) to sit for the CPA exam with fewer tot

• Progesterone s metabolite THP may also be mediating burying

  2021-05-11

  

  Progesterone's metabolite, 3α,5α-THP, may also be mediating burying and freezing responses. Results show female Long–Evans rats in behavioral estrous have higher P4 levels in serum, this explanation and hippocampus compared to diestrous female Long–Evans rats. Additionally, ovx female Long–Evans ra

• It has previously been shown that human

  2021-05-11

  

  It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of BD 1047 dihydrobromide mg on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] re

• Cantharidin is a natural element extracted from blister

  2021-05-11

  

  Cantharidin is a natural element extracted from blister beetles, and has been proven to be effective in cancer [16]. NCTD, the demethylated analog of cantharidin, has been synthesized and been shown to have an equal anti-cancer effect with fewer side effects than cantharidin [39]. It was confirmed t

• Developmental relationships between CD bright and CD

  2021-05-11

  

  Developmental relationships between CD56bright and CD56dim NK L-365,260 remain unresolved; however, several studies indicate that the former is a precursor of the latter. An NK subset with intermediate features between CD56bright and CD56dim has been identified, corroborating this developmental tra

• Why are Tfh cell dynamics so

  2021-05-11

  

  Why are Tfh cell dynamics so fundamentally different in naive and immune animals? Initially, GC Rp-8-Br-PET-cGMPS must pass stringent affinity and specificity checkpoints to ensure only high-affinity non-self-reactive cells are selected. Therefore, restricting primary Tfh cells with the greatest he

• br STAR Methods br Acknowledgments We

  2021-05-11

  

  STAR★Methods Acknowledgments We are grateful to Matthias Mayer at ZMBH in Heidelberg for access to his CD-spectrometer and his help in data interpretation. Technical support by Wolfgang Weinig is gratefully acknowledged. This project was financially supported by the European Union as part of t

• Tamoxifen is included in the

  2021-05-11

  

  Tamoxifen is included in the treatment protocol of ER+ breast carcinoma patients routinely. Although tamoxifen improves patients' survival, unfortunately a large number of ER+ patients don't response to tamoxifen treatment (Yager and Davidson, 2006). Detection of molecular markers which could take a

• br Introduction Coping with DNA

  2021-05-11

  

  Introduction Coping with DNA damage is possible thanks to surveillance mechanisms (checkpoints), that detect the problem and promote its solution [1], [2], and to repair and tolerance pathways that remove the lesions or reduce the damage consequences [3], [4]. Failures in these processes have a h

13555 records 593/904 page Previous Next First page 上5页 591592593594595 下5页 Last page